Memory master and anesthesia iso#

Thus, different anesthetics distinctly alter hippocampal network dynamics, synaptic connectivity, and memory consolidation, with implications for GA strategy appraisal in animal research and clinical settings.Ĭitation: Yang W, Chini M, Pöpplau JA, Formozov A, Dieter A, Piechocinski P, et al. Correspondingly, memory consolidation was impaired after exposure to Keta/Xyl and MMF, but not Iso.

Memory master and anesthesia iso#

Iso anesthesia most closely resembled unperturbed activity during wakefulness and sleep, and network alterations recovered more readily than with Keta/Xyl and MMF. CA1 network activity under all 3 anesthetics was different to natural sleep.

GAs robustly reduced spiking activity, decorrelated cellular ensembles, albeit with distinct activity signatures, and altered spine dynamics. Using extracellular recordings, chronic 2-photon imaging, and behavioral analysis, we monitor the effects of isoflurane (Iso), medetomidine/midazolam/fentanyl (MMF), and ketamine/xylazine (Keta/Xyl) on network activity and structural spine dynamics in the hippocampal CA1 area of adult mice.

How different types of general anesthetics (GAs) affect the hippocampus, a brain region central to memory formation and consolidation, is poorly understood. Yet, long-term memory impairment is an undesirable side effect. General anesthesia is characterized by reversible loss of consciousness accompanied by transient amnesia.